Take 30 to 60 minutes before lights-out
Pinned to before bed, the best window for GABA.
Take 30 to 60 minutes before lights-out
Used for relaxation; effects are individual. Best window is before bed, optional food. Educational only, not medical advice.
GABA (gamma-aminobutyric acid) is the brain's main inhibitory neurotransmitter. Oral supplemental GABA is controversial because its ability to cross the blood-brain barrier is limited in healthy adults, but a portion of users report meaningful calming effects, possibly via gut-vagus signaling or enteric GABA receptors. Trial data is small and mixed.
Used for relaxation. Effects are individual, some feel it strongly, others not at all.
30 to 60 minutes before bed, 100 to 300 mg on an empty stomach. Effects are individual, run a one-to-two-week trial and judge whether you feel a difference. Pair with L-theanine if you want a daytime calming option, theanine has stronger evidence for the alpha-wave relaxation effect. Avoid stacking with prescribed sedatives, sleep medications, or alcohol.
| Window | Fit | Note |
|---|---|---|
| Morning | Poor | Calming effect works against the day |
| Midday | Okay | Fine if the preferred window is not possible |
| Evening, 1-2h before bed | Best | Aligns with winding down |
PharmaGABA (a fermented form) is the version with the most user reports of a perceptible effect. Synthetic GABA is cheaper and used in most generic capsules. Powders dissolve into water but taste mildly fishy.
| Form | Notes |
|---|---|
| capsule | Standard delivery, neutral taste. |
| powder | Flexible dose, ideal when scaling up gram-level intake. |
Who takes it: Adults with bedtime anxiety, mind-racing sleep onset, or stress-induced muscle tension, generally as part of a broader wind-down stack rather than a standalone fix.
Debated, some forms may, but effects vary widely between people.
L-Theanine
Often paired with caffeine in the morning or used to wind down.
Magnesium Glycinate
Calming form of magnesium; supports wind-down.
Glycine
Supports sleep onset; take ~30 minutes before bed.
Melatonin
Take 30-60 minutes before lights-out.
Valerian Root
Mild sedative herb; take 30-60 minutes before bed.
OptimalNourish is strictly educational. We do not recommend dosages, diagnose conditions, or suggest treatments. Always consult a qualified healthcare professional before changing your supplement routine.
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