Methylsulfonylmethane (MSM): what to pair and what to space apart

When something has to be spaced apart, two slots are almost always enough. Put one group with your first meal and the other with your evening meal, roughly 8 to 12 hours apart, which comfortably clears the 2-hour intervals absorption conflicts require. Methylsulfonylmethane (MSM) goes in the earlier slot, and anything it competes with goes in the other. Trying to run three or four slots is where routines break down, most people can hold two.

Absorption conflicts are dose-dependent, not absolute. Trace amounts in food, a splash of milk in coffee or the calcium in a slice of bread, are not the same as a 500mg supplement, and are not worth restructuring your day around. The interactions worth respecting are between two supplements at supplemental doses taken in the same swallow. If you are only taking Methylsulfonylmethane (MSM) and nothing else, spacing is a non-issue, keep it in a fixed slot and move on.

• Other minerals (space by 2+ hours)

• Best time to take Methylsulfonylmethane (MSM)?+

  With a meal, with food.
• Can I take Methylsulfonylmethane (MSM) with other supplements?+

  Most pairings are fine. Space minerals (calcium, iron, zinc, magnesium) by ~2 hours from each other for best absorption.
• Is it OK to miss a day?+

  Yes. Skip the missed dose and continue the next day, don't double up.
• Can I take Methylsulfonylmethane (MSM) in the same handful as everything else?+

  Not quite. Methylsulfonylmethane (MSM) has documented conflicts with Other minerals (space by 2+ hours), which is what the spacing table above is for. Everything else can go in the same slot.
• Is spacing measured from swallowing or from digestion?+

  From swallowing. The intervals in the table are conventional practical margins that allow the first dose to clear the absorption window in the upper small intestine before the second arrives. There is no need to be precise to the minute, being roughly two hours apart is the point.